Reviewing studies of the effects of exercise on brain function, study authors Arthur F. Kramer, PhD, Kirk I. Erickson, PhD and Stanley J. Colcombe of the University of Illinois at Urbana – Champaign said in a press release, "Our review of the last 40 years of research does offer evidence that physical exercise can have a positive influence on cognitive and brain functions in older animal and human subjects." Findings from the review were presented at the 114th Annual Convention of the American Psychological Association (APA).
Exercise Decreases Dementia and Alzheimer's Disease
Looking at epidemiologic studies, they found significant evidence that exercising decreased the risk of dementia later in life. Some studies showed a decrease in risk of Alzheimer's Disease for those who exercised for at least 15-30 minutes at a time three times a week.
Exercise Improves Brain Function
One four-year study found that 62-70 year olds who continued to work or who exercised had better scores in measures of cognition compared to inactive retirees.
Kramer cautions that they don't yet know what is the cause and what is the effect, or which kinds of exercise are best.
Walk and Concentrate Better
A study that assigned older adults either to a walking group or a stretching/toning group found that those in the walking group were less distractible and could concentrate better.
"From this review we have found that physical and aerobic exercise training can lower the risk for developing some undesirable age-related changes in cognitive and brain functions," said Dr. Kramer in a press release, "and also help the brain maintain its plasticity - ability to cover one function if another starts failing later in life."
Updated: August 20, 2006
Source: Presentation: "Fitness Training and the Brain: From Molecules to Minds," Arthur F. Kramer, PhD, Stanley J. Colcombe, PhD, Kirk Erickson, PhD, and Paige Scalf, PhD, University of Illinois at Urbana – Champaign. August, 2006.
Original Press Release (source for article) below:
Exercise helps sustain mental activity as we age, may prevent dementia-like illnesses
Researchers will next zero in how much and what types of exercise keep us cognitively young
New Orleans -- Based on a review of studies on exercise and its effect on brain functioning in human and animal populations, researchers find that physical exercise may slow aging's effects and help people maintain cognitive abilities well into older age. Animals seem to benefit from exercise too and perform spatial tasks better when they are active. Furthermore, fitness training – an increased level of exercise – may improve some mental processes even more than moderate activity, say the authors of the review.
Findings from the review will be presented at the 114th Annual Convention of the American Psychological Association (APA).
Varying opinions still exist on the benefits of exercise and activity, said authors Arthur F. Kramer, PhD, Kirk I. Erickson, PhD and Stanley J. Colcombe of the University of Illinois at Urbana – Champaign, "but our review of the last 40 years of research does offer evidence that physical exercise can have a positive influence on cognitive and brain functions in older animal and human subjects." Different methodologies were examined to comprehensively study what effects exercise can have.
The researchers first examined the epidemiological literature of diseases to determine whether exercise and physical activity can at certain points in a person's lifetime improve cognitive ability and decrease the likelihood of age-related neurological diseases, like Alzheimer's. The authors then reviewed longitudinal randomized trial studies to see if specific fitness training had an affect on cognition and brain function in older adults. Finally, animal studies were examined to understand the molecular and cellular mechanisms responsible for exercise effects on the brain as well as on learning and memory.
Based on a review of the epidemiological literature, the authors found a significant relationship between physical activity and later cognitive function and decreased occurrence of dementia. And the benefits may last several decades. In a few of the studies that examined men and women over 65 years old, the findings showed that those who exercised for at least 15-30 minutes at a time three times a week were less likely to develop Alzheimer's Disease, even if they were genetically predisposed to the disease.
By examining the human intervention studies, a relationship was also found between fitness training and improved cognition, more efficient brain function and retained brain volume in older people, said Kramer. He cautions that different fitness training regimens and aspects of mental functions need further study to solidify a causal relationship. But, he added, there are some preliminary positive findings. In a four year study looking at the relationship between physical activity on cognition and brain function in 62-70 year olds, "those who continued to work and retirees who exercised showed sustained levels of cerebral blood flow and superior performance on general measures of cognition as compared to the group of inactive retirees," said Kramer.
Other studies confirmed the evidence that fitness does have positive effects on brain function in older adults. A study of older adults who were randomly assigned to either a walking group or a stretching and toning control group for six months found that those in the walking group were better able to ignore distracting information in a distractibility task than those in the control group. "Aerobically trained older adults showed increased neural activities in certain parts of the brain that involved attention and reduced activity in other parts of the brain that are sensitive to behavioral conflict," said Kramer.
Animal studies also provide support for the aging benefits of physical activity. Analyzing the effects of exercise in animal populations provides a unique window into learning about exercise-induced neurological and cognitive plasticity – the ability of parts of the brain to function in place of other parts of the brain, said Dr. Kramer. Some of the animal studies reviewed used voluntary-wheel running experiments to show the existence of performance benefits of wheel running on hippocampus-related spatial learning tasks. Moreover, a few studies found that aged rodents that exercised in a water maze learned and retained information about a hidden platform better than age-matched controls.
Exercise also protected both young and aged animals from developing some age-related diseases as indicated by increases in certain neurochemical levels that can offset or prevent certain pathological diseases.
"From this review we have found that physical and aerobic exercise training can lower the risk for developing some undesirable age-related changes in cognitive and brain functions," said Dr. Kramer, "and also help the brain maintain its plasticity - ability to cover one function if another starts failing later in life."
More research is needed to know exactly how much and what types of exercise produce the most rapid and significant effects on thinking and the brain; how long exercise effects last following the end of training; or how much exercise is needed to get continued benefits, said Kramer.
Presentation: "Fitness Training and the Brain: From Molecules to Minds," Arthur F. Kramer, PhD, Stanley J. Colcombe, PhD, Kirk Erickson, PhD, and Paige Scalf, PhD, University of Illinois at Urbana – Champaign
Session 2028 - Invited Symposium: Optimal Aging and Cognition – Moderators of Cognitive Change and Decline, 8:00 – 9:50 AM, Friday, August 11, Morial Convention Center, Second Level, Meeting Room 278
Full text of the article is available from the APA Public Affairs Office
Dr. Kramer can be contacted by phone at (217) 244-1933 or by email at email@example.com.
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